Dynamic heterogeneity influences the leader-follower dynamics during epithelial wound closure.

ABSTRACT: Cells of epithelial tissue proliferate and pack together to attain an eventual density homeostasis. As the cell density increases, spatial distribution of velocity and force show striking similarity to the dynamic heterogeneity observed elsewhere in dense granular matter. While the physical nature of this heterogeneity is somewhat known in the epithelial cell monolayer, its biological relevance and precise connection to cell density remain elusive. Relevantly, we had demonstrated how large-scale dynamic heterogeneity in the monolayer stress field in the bulk could critically influence the emergence of leader cells at the wound margin during wound closure, but did not connect the observation to the corresponding cell density. In fact, numerous previous reports had essentially associated lon

SUBMITTER: Vishwakarma M 

PROVIDER: S-EPMC7423383 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature