Design and analysis of nested case-control studies for recurrent events subject to a terminal event.

ABSTRACT: The process by which patients experience a series of recurrent events, such as hospitalizations, may be subject to death. In cohort studies, one strategy for analyzing such data is to fit a joint frailty model for the intensities of the recurrent event and death, which estimates covariate effects on the two event types while accounting for their dependence. When certain covariates are difficult to obtain, however, researchers may only have the resources to subsample patients on whom to collect complete data: one way is using the nested case-control (NCC) design, in which risk set sampling is performed based on a single outcome. We develop a general framework for the design of NCC studies in the presence of recurrent and terminal events and propose estimation and inference for a joint frail

SUBMITTER: Jazic I 

PROVIDER: S-EPMC7423396 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature