A spatial joint analysis of metal constituents of ambient particulate matter and mortality in England.

ABSTRACT: Few studies have investigated associations between metal components of particulate matter on mortality due to well-known issues of multicollinearity. Here, we analyze these exposures jointly to evaluate their associations with mortality on small area data. We fit a Bayesian profile regression (BPR) to account for the multicollinearity in the elemental components (iron, copper, and zinc) of PM₁₀ and PM_2.5. The models are developed in relation to mortality from cardiovascular and respiratory disease and lung cancer incidence in 2008-2011 at a small area level, for a population of 13.6 million in the London-Oxford area of England. From the BPR, we identified higher risks in the PM₁₀ fraction cluster likely to represent the study area, excluding London, for car

SUBMITTER: Lavigne A 

PROVIDER: S-EPMC7423532 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature