Analysis of the Relaxometric Properties of Extremely Rapidly Exchanging Gd³⁺ Chelates: Lessons from a Comparison of Four Isomeric Chelates.

ABSTRACT: Relaxometric analyses and in particular the use of fast-field cycling techniques have become routine in the study of paramagnetic metal complexes. The field dependence of the solvent proton relaxation properties (nuclear magnetic relaxation dispersion, NMRD) can provide unparalleled insights into the chemistry of these complexes. However, analyzing NMRD data is a multiparametric problem, and some sets of variables are mutually compensatory. Specifically, when fitting NMRD profiles, the metal-proton distance and the rotational correlation time constant have a push-pull relationship in which a change to one causes a predictable compensation in the other. A relaxometric analysis of four isomeric chelates highlights the pitfalls that await when fitting the NMRD profiles of chelates for which d

SUBMITTER: Webber BC 

PROVIDER: S-EPMC7423567 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature