Toward a Revised Nosology for Attention-Deficit/Hyperactivity Disorder Heterogeneity.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is among the many syndromes in the psychiatric nosology for which etiological signal and clinical prediction are weak. Reducing phenotypic and mechanistic heterogeneity should be useful to arrive at stronger etiological and clinical prediction signals. We discuss key conceptual and methodological issues, highlighting the role of dimensional features aligned with Research Domain Criteria and cognitive, personality, and temperament theory as well as neurobiology. We describe several avenues of work in this area, utilizing different statistical, computational, and machine learning approaches to resolve heterogeneity in ADHD. We offer methodological and conceptual recommendations. Methodologically, we propose that an integrated approach utilizing

SUBMITTER: Nigg JT 

PROVIDER: S-EPMC7423612 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature