Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.

ABSTRACT: Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatment (ELM) is a risk factor for developing FND, yet few studies have investigated brain network-trauma relationships in this population. In this neuroimaging-gene expression study, we used two graph theory approaches to elucidate ELM subtype effects on resting-state functional connectivity architecture in 30 patients with motor FND. Twenty-one individuals with comparable depression, anxiety, and ELM scores were used as psychiatric controls. Thereafter, we compared trauma endophenotypes in FND with regional differences in transcriptional gene expression as measured by the Allen Human Brai

SUBMITTER: Diez I 

PROVIDER: S-EPMC7423688 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature