Stability in effects of different smoking-related polygenic risk scores over age and smoking phenotypes.

ABSTRACT:

Purpose

Polygenic risk scores (PRSs) for smoking behavior largely fail to consider the demonstrated developmental change in genetic influence over age and stage of smoking behaviors. Additionally, few studies have examined how stage-specific smoking PRSs (e.g. for initiation vs. smoking heaviness) generalize to other stages of risk. The current study examines the stability of PRS effects over age, and how specifically calibrated PRSs associate with other smoking phenotypes.

Methods

7228 participants were from the National Longitudinal Study of Adolescent to Adult Health, who had calculated PRSs for two smoking phenotypes, Centers for Disease Control and Prevention (CDC) smoking initiation status, and cigarettes per day (CPD). Four time-varying effects models estimated associ

SUBMITTER: Deutsch AR 

PROVIDER: S-EPMC7423706 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature