Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES).

ABSTRACT:

Background

Defective human TLR3 signaling causes recurrent and refractory herpes simplex encephalitis/encephalopathy. Children with febrile infection-related epilepsy syndrome with refractory seizures may have defective TLR responses.

Methods

Children with febrile infection-related epilepsy syndrome were enrolled in this study to evaluate TLR1-9 responses (IL-6, IL-8, IL-12p40, INF-α, INF-γ, and TNF-α) in their peripheral blood mononuclear cells (PBMCs) and monocyte-derived dendritic cells (MDDCs), compared to those with febrile seizures and non-refractory epilepsy with/without underlying encephalitis/encephalopathy.

Results

Adenovirus and enterovirus were found in throat cultures of enrolled patients (2-13 years) as well as serologic IgM elevation of mycoplasma pneum

SUBMITTER: Hsieh MY 

PROVIDER: S-EPMC7424096 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature