Features of resistance-associated substitutions after failure of multiple direct-acting antiviral regimens for hepatitis C.

ABSTRACT:

Background & aims

We aimed to clarify the features of resistance-associated substitutions (RASs) after failure of multiple interferon (IFN)-free regimens in HCV genotype 1b infections.

Methods

A total of 1,193 patients with HCV for whom direct-acting antiviral (DAA) treatment had failed were enrolled from 67 institutions in Japan. The RASs in non-structural protein (NS)3, NS5A, and NS5B were determined by population sequencing.

Results

Failure of 1, 2, and 3 regimens was observed in 1,101; 80; and 12 patients, respectively. Among patients with failure of 1 regimen, Y56H and D168V in NS3 were more frequently detected after failure of paritaprevir, whereas D168E was more frequently detected after failure of regimens including asunaprevir. R30H and L31-RAS in NS5A were f

SUBMITTER: Itakura J 

PROVIDER: S-EPMC7424232 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature