Education and Cognitive Decline: An Integrative Analysis of Global Longitudinal Studies of Cognitive Aging.

ABSTRACT:

Background

The objective of this study was to examine the association between education and incidence of accelerated cognitive decline.

Methods

Secondary analyses of data from the Health and Retirement Study (HRS), a nationally representative prospective cohort study of U.S. residents were conducted (N = 28,417). Cox proportional hazards survival models were layered on longitudinal mixed-effects modeling to jointly examine healthy cognitive aging and incidence of accelerated cognitive decline consistent with patterns seen in preclinical Alzheimer's disease and related dementias (ADRD). Replication analyses were completed on a database including 62,485 additional respondents from HRS sister studies. Life expectancy ratios (LER) and 95% confidence intervals (CIs) were reported

SUBMITTER: Clouston SAP 

PROVIDER: S-EPMC7424268 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature