Secretion of parathyroid hormone may be coupled to insulin secretion in humans.

ABSTRACT:

Objective

Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.

Methods

Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).

Results

The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with

SUBMITTER: Sass MR 

PROVIDER: S-EPMC7424341 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature