Potential Molecular Mechanism of the NPPB Gene in Postischemic Heart Failure with and without T2DM.

ABSTRACT:

Background

This study is aimed at investigating natriuretic peptide B (NPPB) coexpression genes and their pathways involved in heart failure (HF) among patients both with and without type 2 diabetes mellitus (T2DM).

Methods

The microarray dataset GSE26887, containing 19 postischemic HF patients' peripheral blood samples (7 with T2DM and 12 without T2DM), was examined to detect the genes coexpressed with NPPB using the corr.test function in the R packet. Furthermore, using online analytical tools, we determined the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, Gene Ontology (GO) annotation, and protein-protein interaction (PPI) network of the coexpression genes. The modules and hub genes of the PPI network were then identified using

SUBMITTER: Guan YZ 

PROVIDER: S-EPMC7424400 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature