Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated with clinical outcomes for individuals who undergo resection.

Methods

Eligible individuals were those who underwent resection of PDAC and consented to targeted sequencing of their primary tumor via Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT). Genomic alterations were determined on the basis of MSK-IMPACT results from formalin-fixed, paraffin-embedded samples. Associations between genomic alterations and clinical outcomes were assessed.

Results

Targeted sequencing was

SUBMITTER: McIntyre CA 

PROVIDER: S-EPMC7424538 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature