Injectable Poly(ethylene glycol) Hydrogels Cross-Linked by Metal-Phenolic Complex and Albumin for Controlled Drug Release.

ABSTRACT: Injectable hydrogel is advantageous as a drug reservoir for controlled drug release since its injectability provides minimally invasive access to internal tissues and irregular-shaped target sites. Herein, we fabricated pH-responsive injectable hydrogels constructed of a supramolecular cross-link network, which contained tannic acid (TA), Fe(III), poly(ethylene glycol) (PEG), and bovine serum albumin (BSA) for controlled drug release. The hydrogel precursors rapidly turned into a gel when co-injected with NaOH in a time scale of seconds. The hydrogel properties and drug release profiles are all tunable by adjusting the concentrations of BSA, NaOH, and doxorubicin (DOX). The Young's moduli range from 3.19 ± 0.93 to 43.24 ± 1.37 kPa that match internal soft tissues. The hydrogel lasts more t

SUBMITTER: Bubpamala T 

PROVIDER: S-EPMC7424574 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature