An Improved Synthesis of the Triethylene Glycol-Substituted 4-(N-Methyl-N-Boc-Amino)Styrylpyridine.

ABSTRACT: An improved five-step synthesis of triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine (6) is described. Using cost-effective starting materials, the developed synthesis route was synthetic, efficient, and chromatographic purification-free. The key point of the work is the one-pot synthesis of tert-butyl methyl(4-vinylphenyl)carbamate through methylation and elimination in the NaH/THF system. The new synthesis route shows the potential to achieve scaled-up preparation of 6 in the future.

SUBMITTER: Jia J 

PROVIDER: S-EPMC7424578 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature