Rapid and Efficient Synthesis of [¹¹C]Trifluoromethylarenes from Primary Aromatic Amines and [¹¹C]CuCF₃.

ABSTRACT: Prior studies have shown that trifluoromethylarenes can be labeled in high molar activities (A _m > 200 GBq/μmol) with positron-emitting carbon-11 (t _1/2 = 20.4 min) by the reaction of the copper(I) derivative of [¹¹C]fluoroform [¹¹C]CuCF₃, with several types of precursors, such as aryl iodides, arylboronic acids, and aryldiazonium salts. Nonetheless, these precursors can be challenging to synthesize, and in the case of diazonium salts, are unstable. Methods that reduce challenges in precursor preparation for the synthesis of [¹¹C]trifluoromethylarenes are desirable to enhance possibilities for developing biologically relevant ¹¹C-labeled compounds as radiotracers for biomedical imaging with positron

SUBMITTER: Young NJ 

PROVIDER: S-EPMC7424730 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature