Reconstructing the blood metabolome and genotype using long-range chromatin interactions.

ABSTRACT:

Background

-Maintenance of tight controls on circulating blood metabolites is crucial to normal, healthy tissue and organismal function. A number of single nucleotide polymorphisms (SNPs) have been associated with changes in the levels of blood metabolites. However, the impacts of the metabolite-associated SNPs are largely unknown because they fall within non-coding regions of the genome.

Objective

-We aimed to identify genes and tissues that are linked to changes in circulating blood metabolites by characterizing genome-wide spatial regulatory interactions involving blood metabolite-associated SNPs.

Method

-We systematically integrated chromatin interaction (Hi-C), expression quantitative trait loci (eQTL), gene ontology, drug interaction, and literature-supported co

SUBMITTER: Fadason T 

PROVIDER: S-EPMC7424797 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature