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Galectin-1 is inversely associated with type 2 diabetes independently of obesity - A SCAPIS pilot study.


ABSTRACT: Objectives:Galectin-1 is a recently discovered adipokine that increases with obesity and increased energy intake in adipose tissue. Our aim was to assess whether serum galectin-1 is associated with type 2 diabetes (T2D) and other parameters of the metabolic syndrome independently of body mass index (BMI) in a cohort from the general population. Methods:In this cross-sectional population-based cohort study from the western part of Sweden, we investigated associations between serum galectin-1, clinical characteristics and inflammatory markers in 989 women and men aged 50-65 years [part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort]. Results:We showed in linear models that serum galectin-1 was independently and: (1) inversely associated with T2D (p?

SUBMITTER: Fryk E 

PROVIDER: S-EPMC7424824 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Galectin-1 is inversely associated with type 2 diabetes independently of obesity - A SCAPIS pilot study.

Fryk Emanuel E   Strindberg Lena L   Lundqvist Annika A   Sandstedt Mikael M   Bergfeldt Lennart L   Mattsson Hultén Lillemor L   Bergström Göran G   Jansson Per-Anders PA  

Metabolism open 20190905


<h4>Objectives</h4>Galectin-1 is a recently discovered adipokine that increases with obesity and increased energy intake in adipose tissue. Our aim was to assess whether serum galectin-1 is associated with type 2 diabetes (T2D) and other parameters of the metabolic syndrome independently of body mass index (BMI) in a cohort from the general population.<h4>Methods</h4>In this cross-sectional population-based cohort study from the western part of Sweden, we investigated associations between serum  ...[more]

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