Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling.

ABSTRACT:

Background

The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an increased risk of cardiovascular complications following chemotherapy. While this increased risk of later occurring structural cardiac remodeling and/or dysfunction has largely been attributed to the cardiotoxic effects of breast cancer therapies, the effect of the breast tumor itself on the heart prior to cancer treatment has been largely overlooked. Thus, the objectives of this study were to assess the cardiac phenotype in breast cancer patients prior to cancer chemotherapy and to determine the effects of human breast cancer cells on cardiomyocytes.

Methods

We

SUBMITTER: Maayah ZH 

PROVIDER: S-EPMC7425133 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature