Transcriptomics of cumulus cells - a window into oocyte maturation in humans.

ABSTRACT:

Background

Cumulus cells (CC) encapsulate growing oocytes and support their growth and development. Transcriptomic signatures of CC have the potential to serve as valuable non-invasive biomarkers for oocyte competency and potential. The present sibling cumulus-oocyte-complex (COC) cohort study aimed at defining functional variations between oocytes of different maturity exposed to the same stimulation conditions, by assessing the transcriptomic signatures of their corresponding CC. CC were collected from 18 patients with both germinal vesicle and metaphase II oocytes from the same cycle to keep the biological variability between samples to a minimum. RNA sequencing, differential expression, pathway analysis, and leading-edge were performed to highlight functional differences betwee

SUBMITTER: Wyse BA 

PROVIDER: S-EPMC7425158 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature