AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report.

ABSTRACT:

Background

The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal therapies. Despite the identification of many prognostic factors, relatively few have made their way into clinical practice.

Methods

In order to assess and improve the performance of the European LeukemiaNet guidelines, we developed novel prognostic models using the biomarkers from the guidelines, age, performance status and select transcript biomarkers. The models were developed separately for mononuclear cells and viable leukemic blasts from previously untreated acute myeloid leukemia patients (discovery cohort, N = 185) who received intensive chemot

SUBMITTER: Pogosova-Agadjanyan EL 

PROVIDER: S-EPMC7425159 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature