Radiographic progression in clinical trials in rheumatoid arthritis: a systemic literature review of trials performed by industry.

ABSTRACT:

Objectives

To summarise radiographic data in randomised controlled trials (RCTs) as part of the radiographic inhibition claim of disease-modifying antirheumatic drugs (DMARDs) approved for patients with rheumatoid arthritis (RA).

Methods

A systemic literature review was performed using the Medline database from 1994 to February 2020. The results were grouped based on the scoring methods (Sharp, Genant modification, van der Heijde modification) and RA patient populations.

Results

One hundred sixty-eight publications were selected. After detailed assessment, 52 RCTs (7 methotrexate (MTX)-naive, 23 MTX inadequate response (IR), 9 DMARDs IR and 3 tumour necrosis factor-alpha inhibitors (TNFi) IR studies) were finally included. Information on patient population, scoring me

SUBMITTER: Park YJ 

PROVIDER: S-EPMC7425197 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature