Dependence, withdrawal and rebound of CNS drugs: an update and regulatory considerations for new drugs development.

ABSTRACT: The purpose of this article is to describe dependence and withdrawal phenomena related to CNS drugs discontinuation and to clarify issues related to the evaluation of clinical drug withdrawal and rebound as they relate to safety in new drug development. The article presents current understanding and definitions of drug dependence and withdrawal which are also relevant and important features of addiction, though not the same. Addiction, called substance use disorder in DSM-5, affects an individual's brain and behaviour, represents uncontrollable drug abuse and inability to stop taking a drug regardless of the harm it causes. Characteristic withdrawal syndromes following abrupt discontinuation of CNS-active drugs from numerous drug classes are described. These include drugs both scheduled an

SUBMITTER: Lerner A 

PROVIDER: S-EPMC7425303 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature