The dynamic of basal ganglia activity with a multiple covariance method: influences of Parkinson's disease.

ABSTRACT: The closed-loop cortico-subcortical pathways of basal ganglia have been extensively used to describe the physiology of these centres and to justify the functional disorders of basal ganglia diseases. This approach justifies some experimental and clinical data but not others, and furthermore, it does not include a number of subcortical circuits that may produce a more complex basal ganglia dynamic than that expected for closed-loop linear networks. This work studied the functional connectivity of the main regions of the basal ganglia motor circuit with magnetic resonance imaging and a new method (functional profile method), which can analyse the multiple covariant activity of human basal ganglia. The functional profile method identified the most frequent covariant functional status (profile

SUBMITTER: Rodriguez-Sabate C 

PROVIDER: S-EPMC7425309 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature