Structural brain networks and functional motor outcome after stroke-a prospective cohort study.

ABSTRACT: The time course of topological reorganization that occurs in the structural connectome after an ischaemic stroke is currently not well understood. We aimed to determine the evolution of structural brain networks in stroke patients with motor deficits and relate changes in their global topology to residual symptom burden and functional impairment. In this prospective cohort study, ischaemic stroke patients with supratentorial infarcts and motor symptoms were assessed longitudinally by advanced diffusion MRI and detailed clinical testing of upper extremity motor function at four time points from the acute to the chronic stage. For each time point, structural connectomes were reconstructed, and whole-hemisphere global network topology was quantified in terms of integration and segregation par

SUBMITTER: Schlemm E 

PROVIDER: S-EPMC7425342 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature