Association of neuroinflammation with episodic memory: a [¹¹C]PBR28 PET study in cognitively discordant twin pairs.

ABSTRACT: Alzheimer's disease is associated with chronic response of innate immune system, referred as neuroinflammation. PET radioligands binding to the 18 kDa translocator protein are potential biomarkers of neuroinflammation. Translocator protein PET studies in mild cognitive impairment and Alzheimer's disease have indicated controversial results, possibly reflecting interindividual variation and heterogeneity of study populations. We controlled for genetic and environmental effects by studying twin pairs discordant for episodic memory performance. Episodic memory impairment is a well-known cognitive hallmark of early Alzheimer's disease process. Eleven same-sex twin pairs (four monozygotic pairs, six female pairs, age 72-77 years) underwent [¹¹C]N-acetyl-N-(2-methoxybenz

SUBMITTER: Lindgren N 

PROVIDER: S-EPMC7425350 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature