Cluster identification, selection, and description in cluster randomized crossover trials: the PREP-IT trials.

ABSTRACT:

Background

In cluster randomized crossover (CRXO) trials, groups of participants (i.e., clusters) are randomly allocated to receive a sequence of interventions over time (i.e., cluster periods). CRXO trials are becoming more comment when they are feasible, as they require fewer clusters than parallel group cluster randomized trials. However, CRXO trials have not been frequently used in orthopedic fracture trials and represent a novel methodological application within the field. To disseminate the early knowledge gained from our experience initiating two cluster randomized crossover trials, we describe our process for the identification and selection of the orthopedic practices (i.e., clusters) participating in the PREP-IT program and present data to describe their key characteristi

SUBMITTER: Sprague S 

PROVIDER: S-EPMC7425374 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature