Oxygenation differs among white matter hyperintensities, intersected fiber tracts and unaffected white matter.

ABSTRACT: White matter hyperintensities of presumed vascular origin are frequently observed on magnetic resonance imaging in normal aging. They are typically found in cerebral small vessel disease and suspected culprits in the etiology of complex age- and small vessel disease-related conditions, such as late-onset depression. White matter hyperintensities may interfere with surrounding white matter metabolic demands by disrupting fiber tract integrity. Meanwhile, risk factors for small vessel disease are thought to reduce tissue oxygenation, not only by reducing regional blood supply, but also by impairing capillary function. To address white matter oxygen supply-demand balance, we estimated voxel-wise capillary density as an index of resting white matter metabolism, and combined estimates of blood

SUBMITTER: Dalby RB 

PROVIDER: S-EPMC7425421 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature