Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited. Studies using skin fibroblasts derived from patients with neurodegenerative disorders demonstrate that cell stress pathways and bioenergetics are altered when compared to healthy individuals. However, findings in MS skin fibroblasts are limited. Here, we collected skin fibroblasts from 24 healthy control individuals, 30 patients with MS, and ten with amyotrophic lateral sclerosis (ALS) to investigate altered cell stress profiles. We observed endoplasmic reticulum swelling in MS skin fibrobla

SUBMITTER: Wilkins JM 

PROVIDER: S-EPMC7425440 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature