Activity or connectivity? A randomized controlled feasibility study evaluating neurofeedback training in Huntington's disease.

ABSTRACT: Non-invasive methods, such as neurofeedback training, could support cognitive symptom management in Huntington's disease by targeting brain regions whose function is impaired. The aim of our single-blind, sham-controlled study was to collect rigorous evidence regarding the feasibility of neurofeedback training in Huntington's disease by examining two different methods, activity and connectivity real-time functional MRI neurofeedback training. Thirty-two Huntington's disease gene-carriers completed 16 runs of neurofeedback training, using an optimized real-time functional MRI protocol. Participants were randomized into four groups, two treatment groups, one receiving neurofeedback derived from the activity of the supplementary motor area, and another receiving neurofeedback based on the cor

SUBMITTER: Papoutsi M 

PROVIDER: S-EPMC7425518 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature