Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women.

ABSTRACT:

Background

Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL deficiency leads to increased susceptibility to infections or not. The aim of this study was to determine if low levels of mannose-binding lectin (MBL) predict sepsis development, sepsis severity and outcome from severe sepsis or septic shock.

Method

Patients aged 18 years or more with documented sepsis within 24 h after admission to the intensive care unit were included if they had participated in a health survey and donated blood samples prior to the sepsis event. A subset of these patients had stored plasma also from the acute phase. Two matched referents free

SUBMITTER: Jacobson S 

PROVIDER: S-EPMC7425558 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature