Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy.

ABSTRACT:

Background

Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered gene expression and DNA methylation are implicated in disease pathogenesis. However, how DNA methylation might functionally impact gene expression and contribute to nerve damage remains unclear. Here, we analyzed genome-wide transcriptomic and methylomic profiles of sural nerves from T2D patients with DPN.

Results

Unbiased clustering of transcriptomics data separated samples into groups, which correlated with HbA1c levels. Accordingly, we found 998 differentially expressed genes (DEGs) and 929 differentially methylated genes (DMGs) between the groups with th

SUBMITTER: Guo K 

PROVIDER: S-EPMC7425575 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature