Metagenomic Profiling of Ocular Surface Microbiome Changes in Meibomian Gland Dysfunction.

ABSTRACT:

Purpose

Ocular surface microbiome changes can affect meibomian gland dysfunction (MGD) development. This study aimed to delineate differences among the microbiome of eyelid skin, conjunctiva, and meibum in healthy controls (HCs) and patients afflicted with MGD.

Methods

Shotgun metagenomic analysis was used to determine if there are differences between the microbial communities in ocular sites surrounding the meibomian gland in healthy individuals and patients afflicted with MGD.

Results

The meibum bacterial content of these microbiomes was dissimilar in these two different types of individuals. Almost all of the most significant taxonomic changes in the meibum microbiome of individuals with MGD were also present in their eyelid skin, but not in the conjunctiva. Such s

SUBMITTER: Zhao F 

PROVIDER: S-EPMC7425691 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature