Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.

ABSTRACT:

Purpose

Prior studies have demonstrated that microglial activation is involved in the pathogenesis of primary open-angle glaucoma (POAG). Here we sought to identify genetic associations between POAG and variants in APOE and TREM2, genes associated with Alzheimer disease (AD) that critically regulate microglial neurodegeneration-associated molecular signature.

Methods

APOE genotypes were called using imputed data from the NEIGHBOR consortium (2120 POAG cases, 2262 controls) and a second cohort from the Massachusetts Eye and Ear Infirmary (MEEI; 486 cases, 344 controls). TREM2 coding variants were genotyped by means of the Illumina HumanExome BeadArray. The data set was analyzed for association with POAG overall, as well as the high-tension glaucoma (HTG) and normal-tension gl

SUBMITTER: Margeta MA 

PROVIDER: S-EPMC7425753 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature