Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins.

ABSTRACT: Negatively charged tissues are ubiquitous in the human body and are associated with a number of common diseases yet remain an outstanding challenge for targeted drug delivery. While the anionic proteoglycans are critical for tissue structure and function, they make tissue matrix dense, conferring a high negative fixed charge density (FCD) that makes drug penetration through the tissue deep zones and drug delivery to resident cells extremely challenging. The high negative FCD of these tissues is now being utilized by taking advantage of electrostatic interactions to create positively charged multi-stage delivery methods that can sequentially penetrate through the full thickness of tissues, create a drug depot and target cells. After decades of work on attempting delivery using strong bindin

SUBMITTER: Vedadghavami A 

PROVIDER: S-EPMC7425807 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature