Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction.

ABSTRACT:

Background

Macrophages and fibroblasts are 2 major cell types involved in healing after myocardial infarction (MI), contributing to myocardial remodeling and fibrosis. Post-MI fibrosis progression is characterized by a decrease in cardiac macrophage content.

Objectives

This study explores the potential of macrophages to express fibroblast genes and the direct role of these cells in post-MI cardiac fibrosis.

Methods

Prolonged in vitro culture of human macrophages was used to evaluate the capacity to express fibroblast markers. Infiltrating cardiac macrophages was tracked in vivo after experimental MI of LysM(Cre^/+);ROSA26(EYFP^/+) transgenic mice. The expression of Yellow Fluorescent Protein (YFP) in these animals is restricted to myeloid lineage a

SUBMITTER: Haider N 

PROVIDER: S-EPMC7425814 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature