MicroRNAs isolated from peripheral blood in the first trimester predict spontaneous preterm birth.

ABSTRACT:

Objective

To predict spontaneous preterm birth among pregnant women in an African American population using first trimester peripheral blood maternal immune cell microRNA.

Study design

This was a retrospective nested case-control study in pregnant patients enrolled between March 2006 and October 2016. For initial study inclusion, samples were selected that met the following criteria: 1) singleton pregnancy; 2) maternal body mass index (BMI) <30 kg/m2; 3) blood sample drawn between 6 weeks to 12 weeks 6 days gestation; 4) live born neonate with no detectable birth defects. Using these entry criteria, 486 samples were selected for study inclusion. After sample quality was confirmed, 139 term deliveries (38-42 weeks) and 18 spontaneous preterm deliveries (<35 weeks) were select

SUBMITTER: Winger EE 

PROVIDER: S-EPMC7425910 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature