The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer.

ABSTRACT:

Introduction

Neighborhood socioeconomic (nSES) factors have been implicated in prostate cancer (PCa) disparities. In line with the Precision Medicine Initiative that suggests clinical and socioenvironmental factors can impact PCa outcomes, we determined whether nSES variables are associated with time to PCa diagnosis and could inform PCa clinical risk assessment.

Materials and methods

The study sample included 358 high risk men (PCa family history and/or Black race), aged 35-69 years, enrolled in an early detection program. Patient variables were linked to 78 nSES variables (employment, income, etc.) from previous literature via geocoding. Patient-level models, including baseline age, prostate specific antigen (PSA), digital rectal exam, as well as combined models (patient p

SUBMITTER: Lynch SM 

PROVIDER: S-EPMC7425919 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature