The differential impacts of non-locally acquired infections and treatment interventions on heterosexual HIV transmission in Hong Kong.

ABSTRACT: INTRODUCTION:Heterosexual infections have contributed to a high proportion of the HIV burden in Asia and Eastern Europe. Human mobility and non-local infections are important features in some cities/countries. An understanding of the determinants of the sustained growth of the heterosexual HIV epidemics would enable the potential impacts of treatment-based interventions to be assessed. METHODS:We developed a compartmental model for heterosexual HIV transmissions, parameterized by clinical and surveillance data (1984-2014) in Hong Kong. HIV sequence data were included for examining genetic linkages and clustering pattern. We performed sensitivity analyses to evaluate effects of high-risk sexual partnership and proportions of non-locally acquired infections. Four hypothetical interventions (

SUBMITTER: Wong NS 

PROVIDER: S-EPMC7425942 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature