Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period.

ABSTRACT: A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods. The interaction of coupling and heterogeneity in circadian clock networks is hypothesized to influence clock's entrainability, but our knowledge of mechanisms governing period heterogeneity within circadian clock networks remains largely elusive. In this study, we aimed to explore the principles that underlie intercellular period variation in circadian clock networks (clonal period heterogeneity). To this end, we employed a laboratory selection approach and derived a panel of 25 clonal cell populations exhibiting circadian periods ranging from 22

SUBMITTER: Nikhil KL 

PROVIDER: S-EPMC7425987 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature