Advances in Understanding the Pathophysiology of Lacunar Stroke: A Review.

ABSTRACT:

Importance

Stroke is the second leading cause of death in the world, and nearly one-third of ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in size, they create large problems, leaving many patients with intellectual and physical disabilities. Because there are limitations in understanding the underlying pathophysiology of LS, the development of novel therapies has been slow.

Observations

When the term lacune was described in the 1800s, its underlying pathophysiological basis was obscure. In the 1960s, C. Miller Fisher, MD, performed autopsy studies that showed that vessels supplying lacunes displayed segmental arteriolar disorganization, characterized by vessel enlargement, hemorrhage, and fibrinoid deposition. For these pathologi

SUBMITTER: Regenhardt RW 

PROVIDER: S-EPMC7426021 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature