Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.

ABSTRACT:

Background

Increasing evidence suggests that conventional adenomas (CAs) and serrated polyps (SPs) represent two distinct groups of precursor lesions for colorectal cancer (CRC). The influence of common genetic variants on risk of CAs and SPs remain largely unknown.

Methods

Among 27 426 participants within three prospective cohort studies, we created a weighted genetic risk score (GRS) based on 40 CRC-related single nucleotide polymorphisms (SNPs) identified in previous genome-wide association studies; and we examined the association of GRS (per one standard deviation increment) with risk of CAs, SPs and synchronous CAs and SPs, by multivariable logistic regression. We also analysed individual variants in the secondary analysis.

Results

During 18-20 years of follow-up

SUBMITTER: Hang D 

PROVIDER: S-EPMC7426026 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature