Olfactory markers for depression: Differences between bipolar and unipolar patients.

ABSTRACT:

Objectives

The aim of the study was to compare olfactory functions between unipolar and bipolar patients according to the thymic states (depressed, euthymic) and determine specific olfactory variations between these different states.

Methods

We recruited 176 participants in 5 groups: depressed bipolar (DB), euthymic bipolar (EB), depressed unipolar (DU), euthymic unipolar (EU), and controls (HC). They were assessed using the Sniffin' sticks threshold and identification tests. Odors' pleasantness, intensity, familiarity and emotion were assessed. Clinical evaluation explored dimensions of depression, mania, anxiety, and anhedonia.

Results

Smell identification was lower in DU compared to EU patients and controls. Pleasant odors received lower hedonic rating in DU and DB

SUBMITTER: Kazour F 

PROVIDER: S-EPMC7426149 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature