The Impact of Insulin-Like Growth Factor Index and Biologically Effective Dose on Outcomes After Stereotactic Radiosurgery for Acromegaly: Cohort Study.

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) is a safe and effective treatment for acromegaly.

Objective

To improve understanding of clinical and dosimetric factors predicting biochemical remission.

Methods

A single-institution cohort study of nonsyndromic, radiation-naïve patients with growth hormone-producing pituitary adenomas (GHA) having single-fraction SRS between 1990 and 2017. Exclusions were treatment with pituitary suppressive medications at the time of SRS, or <24 mo of follow-up. The primary outcome was biochemical remission-defined as normalization of insulin-like growth factor-1 index (IGF-1i) off suppression. Biochemical remission was assessed using Cox proportional hazards. Prior studies reporting IGF-1i were assessed via systematic literature review and

SUBMITTER: Graffeo CS 

PROVIDER: S-EPMC7426191 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature