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The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.

ABSTRACT: Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LEC) neurons across days to understand how sensory representations are modified by experience. We found representations of odors in DG GCs that required synaptic input from the LEC. Odor classification accuracy in DG GCs correlated with future behavioral discrimination. In associative learning, DG GCs, more so than LEC neurons, changed their responses to odor stimuli, increasing the distance in neural representations between stimuli, responding more to the conditioned and less to the unconditioned odorant. Thus, with learning, DG GCs amplify the decodability of cortical representations of important stimuli, which may facilitate information storage to guide behavior.

SUBMITTER: Woods NI

PROVIDER: S-EPMC7426196 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.

Woods Nicholas I NI Stefanini Fabio F Apodaca-Montano Daniel L DL Tan Isabelle M C IMC Biane Jeremy S JS Kheirbek Mazen A MA

Neuron 20200430 1

Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LEC) neurons across days to understand how sensory representations are modified by experience. We found representations of odo ...[more]

PMID: 32359400

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Dataset Information

The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.

Publications

The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.

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