Inverse changes in raphe and cortical 5-HT_1B receptor availability after acute tryptophan depletion in healthy human subjects.

ABSTRACT: Serotonergic neurotransmission plays a key role in the pathophysiology and treatment of various neuropsychiatric diseases. The purpose of this study was to investigate changes in serotonergic neurotransmission after acute tryptophan depletion (ATD) using positron emission tomography (PET) with [¹¹ C]P943, a 5-HT_1B receptor radioligand previously shown to be sensitive to changes in 5-HT. Five healthy subjects were scanned on a high resolution PET scanner twice on the same day, before and approximately 5 hours after ingesting capsules containing an amino acid mixture that lacks tryptophan. For each scan, emission data were acquired for 120 min after intravenous bolus injection of [¹¹ C]P943. Binding potential (BP_ND ) values were estimated from para

SUBMITTER: Baldassarri SR 

PROVIDER: S-EPMC7426238 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature