The decreased expression of IKBKE in systemic lupus erythematosus.

ABSTRACT:

Objective

The IKBKE has been proven to be associated with systemic lupus erythematosus (SLE) in a genome-wide association study (GWAS) conducted by our group. The objective of the recent study is to investigate the contribution of IKBKE functional variants (rs2297550) to SLE.

Methods

We detected the regulatory effect of rs2297550 on IKBKE expression by expression quantitative trait loci (eQTL) study. Then, we investigated the differences of IKBKE mRNA expression levels in peripheral blood mononuclear cells (PBMCs) between 135 SLE patients and 130 healthy controls using quantitative real-time PCR (qRT-PCR). We further analyzed the association of SLE clinical characteristics with IKBKE mRNA expression and rs2297550 polymorphisms.

Results

The results of eQTL indicated th

SUBMITTER: Zhu T 

PROVIDER: S-EPMC7426285 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature