Preclinical Validation of SilkBridge^TM for Peripheral Nerve Regeneration.

ABSTRACT: Silk fibroin (Bombyx mori) was used to manufacture a nerve conduit (SilkBridge^TM) characterized by a novel 3D architecture. The wall of the conduit consists of two electrospun layers (inner and outer) and one textile layer (middle), perfectly integrated at the structural and functional level. The manufacturing technology conferred high compression strength on the device, thus meeting clinical requirements for physiological and pathological compressive stresses. As demonstrated in a previous work, the silk material has proven to be able to provide a valid substrate for cells to grow on, differentiate and start the fundamental cellular regenerative activities in vitro and, in vivo, at the short time point of 2 weeks, to allow the starting of regenerative proce

SUBMITTER: Fregnan F 

PROVIDER: S-EPMC7426473 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature