SIRT1 Activation by Natural Phytochemicals: An Overview.

ABSTRACT: Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD⁺ as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its

SUBMITTER: Iside C 

PROVIDER: S-EPMC7426493 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature