Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies.

ABSTRACT: The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identify several types of cells, which carry a risk for a disease progression and subsequent post-therapeutic relapse. Cancer stem cells (CSCs) are a subpopulation of tumor cells that can drive tumor initiation and can cause relapses. At the time point of tumor initiation, CSCs originate from either differentiated cells or adult tissue resident stem cells. Due to their importance, several biomarkers that characterize CSCs have been identified and correlated to diagnosis, therapy and prognosis. However, CSCs have been shown to display a high plasticity, which cha

SUBMITTER: Walcher L 

PROVIDER: S-EPMC7426526 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature